Discoveries & Breakthroughs Inside Biophysics

Unlocking Mysteries of Sharks

Marine Scientists Developing First Whale Shark Genome, Reveal Ancestry Details

July 1, 2011

Marine scientists are developing the first whale shark genome—all of the hereditary information enclosed in the animal’s DNA. Scientists can decode the genetic material and analyze all of the different chemicals therein. This gives scientists a snapshot into information on the animal—the ocean’s largest fish. This data can help scientists understand more about the animal and its ancestors, who were the first creatures to develop an adaptive immune response and create their own antibodies.

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HOW GENES WORK: Everyone has a set of chromosomes, each containing two halves, one from each parent, and each containing a complete set of genes, so that each chromosome has two copies of every gene. The "dominant" gene is the one that is expressed, such as for brown eyes. A "recessive" gene produces a particular trait -- for instance, for blue eyes -- only if its effects are not over-ridden by those of a dominant gene. Genes are normally transmitted unchanged from one generation to the next, but sometimes a mutation occurs: the structure of the gene is changed. Genetic engineers study these mutations in hopes that it may one day be possible to correct errors in genetic coding that are responsible for specific diseases or disorders.

WHAT IS DNA? DNA is the blueprint that encodes all the data for building a human body, along with instructions on how it should operate. Every cell in a person's body contains a copy of this DNA. DNA typing is based on an unusual feature found in the human genome. There are multiple copies of certain short sequences, 3 to 30 base pairs long, that are repeated one after another as many as 100 times. These groups of repeat sequences are widely scattered through the genome. Everyone has these repeat units, but the number varies from person to person. Only identical twins will have the same numbers and patterns of these sequences. These genetic data aren't instructions to make anything; scientists think they might exist to get mixed up in the regular genes and provide some variety for evolution.

The Biophysical Society contributed to the information contained in the TV portion of this report.

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Ellen Weiss
Biophysical Society
eweiss@biophysics.org
Phone:  240-290-5606