Asthma and Your Genes

Pulmonologists, Molecular Biologists Discover Genetically-Based Response to Common Drug

January 1, 2005

Albuterol, the most popular drug for treating asthma attacks, works by binding to receptors in the muscle cells that surround the airways, causing the muscles to relax. However, researchers discovered that the receptors in one in six people are genetically different from the most common form, causing a different response and offering hope for more specialized treatments of these patients.

What is asthma?

Science behind the news is funded by a generous grant from the NSF

Asthma is a chronic lung condition that makes it difficult to breathe. People with asthma have airways that are very sensitive and easily irritated. When those airways become inflamed, they narrow so that the air can't move in and out as easily. Symptoms of asthma include wheezing, coughing, tightness in the chest, and shortness of breath. Each of these can aggravate the other symptoms, so the sufferer is caught in a vicious cycle. And if the airways constrict too much, oxygen cannot reach vital organs. People can die from severe asthma attacks.

Asthma is not technically an allergy, but common allergens are most likely to trigger an attack. Inflammation is the body's response to foreign or toxic substances that come into contact with the body. Allergens such as pollen, house dust mites and animal dander can all trigger an immune system reaction in the airways. Just like a bacterial infection, this signals the body to bring white blood cells to the irritated area, and these attack the allergens.

In the process, the tissues of the bronchial tubes can become damaged. So the tubes become hyper-sensitive and over-react to things that would not previously have triggered a reaction: cold weather, pollution, dry air, or chemical odors, for instance. The bronchial tubes can also go into spasms and narrow, causing wheezing. Mucus can't be as easily cleared and accumulates in the bronchial tubes, setting off a cough reflex to clear the extra mucus out of airways.

Video help

Latest stories

Did you know?...

Asthma is the most common chronic respiratory disease in children, affecting between 7 and 10 percent of children, and accounting for one-quarter of all absenteeism from school. Asthma affects twice as many boys as girls in childhood, but more girls than boys develop the condition as teenagers. By adulthood, both genders are affected equally.

More information on this story

Martha J. Heil
mheil@aip.org
American Institute of Physics
Tel: 301-209-3088