Kissing Puberty

Neuroendocrinologists Unlock Chemical Trigger to Puberty

May 1, 2005

Researchers have discovered the precise chemical chain reaction that could be the much-sought-after puberty trigger: The KiSS-1 gene, which produces a protein in the hypothalamus, a part of the brain, which regulates metabolic activity. When the protein connects with a receptor on another gene called GPR54, puberty is believed to begin. This knowledge may guide the development of better drugs for treating hormone disorders related to puberty.

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What happens to the body during puberty?

Science behind the news is funded by a generous grant from the NSF

Puberty is the developmental stage where a child starts to become sexually mature. It can occur between ages 8 and 11 for girls, and 9 to 12 for boys.

As a child nears maturity, the brain -- specifically the parts known as the hypothalamus and the pituitary gland -- releases chemicals called hormones. The hormones regulate the reproductive organs of both males and females. Girls produce estrogen and progesterone, while boys produce testosterone. Growth hormones also begin to work, causing the body to become larger, sometimes very quickly. The body also makes follicle stimulating hormones, leading to hair growth.

All these extra hormones give rise to dramatic changes in the body.

The first sign of puberty in girls is breast development. Then hair starts growing in the pubic area and armpits, followed by acne around age 13. Menstruation is typically the last stage to occur.

In boys, the larynx lengthens and the voice "breaks" and then deepens. Also, there is growth in the testicles and penis, followed by hair growth in the pubic region and armpits. Acne and facial hair are the last developments.

Both girls and boys may also experience strong emotions or mood changes.


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Did you know?...

  • If a child shows signs of development earlier than usual -- before age 8 in a girl, or 9-1/2 for a boy -- it is called precocious puberty. Puberty can sometimes be delayed if a child suffers from malnutrition: not eating enough of the right kinds of foods.
  • Adolescence is the period of transition between puberty and adulthood. Most girls are physically mature by age 14; boys mature at around 15 or 16.

More information on this story

Martha J. Heil
mheil@aip.org
American Institute of Physics
Tel: 301-209-3088