Detecting Disease in Less Than 60 Seconds

Viral Immunologists Invent Speedy Virus Identification Technique

September 1, 2008

Chemists and immunologists devised a new rapid system for detecting and identifying viruses. It uses surface enhanced Raman spectroscopy to measure the frequency of near-infrared laser light as it scatters off viral DNA and RNA. After a swab of a person's nasal passage, the technique can detect individual virus particles quickly and identify many types.

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WHAT IS A VIRUS? Unlike bacteria, viruses are not cells; they consist of DNA or RNA molecules, containing the virus's genes, surrounded by a protein coat. A virus can attach itself to cells and inject molecules into the cell, or the cell may absorb it. Once inside, the molecules cause the infected cell to make new viruses that can spread to other cells.

WHAT IS SPECTROSCOPY? Spectroscopy is a technique often used by astronomers and physicists to study the make-up of an object based on the light it emits. In this case it is used to identify the scattering of light off of the DNA and RNA within viruses. This is possible because each chemical element has a unique signature, emitting or absorbing radiation at specific wavelengths. For example, sodium, used in street lights, emits primarily orange light. Oxygen, used in neon lights, emits green light. By passing the light from a star or other object through a special instrument, called a spectrograph, the light is "spread" into a spectrum in much the same way visible light is spread into its colors by a prism. By carefully studying how the spectrum becomes brighter or darker at each wavelength, scientists can tell what chemical elements are present.

The Optical Society of America and the Biophysical Society contributed to the information contained in the TV portion of this report.

This report has also been produced thanks to a generous grant from the Camille and Henry Dreyfus Foundation, Inc.

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To Go Inside This Science:
Ralph A. Tripp, Ph.D.
University of Georgia
Athens, GA 30602
rtripp@vet.uga.edu
706-542-1557

Optical Society of America
Washington, DC 20036-1023
202-223-8130
info@osa.org

Ellen Weiss
Director of Policy Communications
Biophysical Society
eweiss@biophysics.org
301-634-7176