Cavity Fighting Candy

Oral Biologists Use Chemistry to Formulate Cavity Fighting Mints

November 1, 2008

Oral biologists formulated a mint that fights cavities with an ingredient called Cavistat. Cavistat contains two main components that protect the teeth. First, the amino acid arginine metabolizes certain bacteria, which neutralizes the acid generated by sugars. This raises the pH to help prevent damage to teeth. Cavistat also introduces other chemical compounds that protect against the dissolving of the minerals of the teeth.

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WHAT DOES IT DO? BasicMints contain Cavistat, a cavity-fighting agent that includes two major components. Cavistat disrupts oral chemistry and biology in two ways. First, it introduces an amino acid called arginine to the mouth. When bacteria in the mouth break the arginine down, it neutralizes the acid generated by sugars in food, which reduces the amount of acid in the mouth and helps prevent damage to teeth. Additionally the Cavistat adds other chemical compounds that protect the minerals that make up teeth from dissolving.

ANATOMY OF A TOOTH: We think of teeth as being the part visible above the gum, but this is only the tip, or crown, of a tooth. There is also a neck that lies at the gum line, and a root, located below the gum. The crown of each tooth has an enamel coating to protect the underlying dentine. Enamel is even harder than bone, thanks to rows of tightly packed calcium and phosphorus crystals. The underlying dentine is slightly softer, and contains tiny tubules that connect with the central nerve of the tooth within the pulp. The pulp forms the central chamber of the tooth, and is made of soft tissue containing blood vessels that carry nutrients to the tooth. It also contains nerves so teeth can sense hot and cold, as well as lymph vessels to carry white blood cells to fight bacteria.

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On The Web: Experimental mints appear to reduce pediatric cavities

To Go Inside This Science:
Dr. Israel Kleinberg
The Health Sciences Center
Stony Brook, NY 11794
631-632-8923
Israel.Kleinberg@stonybrook.edu

American Association of Pharmaceutical Scientists
Tom Huddleston
Communications Specialist
703-248-4744
HuddlestonT@aaps.org