Pain Relief for Pets

Veterinarian Anesthesiologists Ease the Pain for Pets and their Owners with New Drug Formula

April 1, 2009

Veterinarian anesthesiologists developed a new opioid drug formula that gives pets extended pain relief--allowing the animal to return home sooner. The formula is encapsulated in liposomes, tiny artificial sacs formed from layers of fat in a cell. The liposomes are used to carry the pain relief drug to targeted cells in the body. A large reservoir of the drug is given as a subcutaneous injection that slowly diffuses from the liposomes into the body over long period of time.

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ABOUT PAIN: Pain is your body's way of sending a warning signal to your brain that something is wrong. The damaged part of the body produces chemicals that irritate the receptor nerve endings in and beneath your skin. These nerve cells send messages in the form of electrical impulses to the brain by way of the spinal cord, much like wires carrying phone calls to a telephone exchange. The spinal cord receives incoming signals and routes them to the correct part of the brain. The chemicals are also what cause an injured body part to swell up so that blood will rush to the site and help heal it. There is more than one kind of pain. "Protective pain" alerts the body to potential danger, such as when you touch a hot burner on the stove. It is usually followed by a reflexive withdrawal of the body part in contact with the source of pain. "Reparative pain" is the dull spreading of pain that accompanies more serious injuries as they heal, such as a broken ankle. "Chronic pain" results from a long-term incurable illness. Nerve fibers become more effective at sending pain signals to the brain, and the brain becomes more sensitive to the pain.

ABOUT PAIN RELIEF: Pain medications alleviate pain either by stopping the transmission of signals from the site of the injury, or reducing their intensity before they reach the brain. For instance, taking aspirin will stop nerve cells from making the chemicals that signal pain, and "lower the volume" on the pain signals that do get through to your brain. Strong pain relievers, such as opioids, are controlled substances and access to them is restricted. The development of a fatty coating to surround powerful drugs, allows them to diffuse slowly into the body, which makes pain treatment easier, and more convenient for pet owners, especially, as they are able to bring their pets home more quickly after surgery.

The American Association of Pharmaceutical Scientists contributed to the information contained in the TV portion of this report.

This report has also been produced thanks to a generous grant from the Camille and Henry Dreyfus Foundation, Inc.

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Tania Banak
University Relations Specialist
University of Wisconsin-Madison School of Veterinary Medicine
Madison, WIż 53706-1102
608-263-6914
banakt@svm.vetmed.wisc.edu

American Association of Pharmaceutical Scientists
Tom Huddleston
Communications Specialist
703-248-4744
HuddlestonT@aaps.org