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Scanning for Skin Cancer

Radiologists, Oncologists Find PET Scans More Accurate for Detecting Recurring Tumors

October 1, 2004

While an initial diagnosis of melanoma is still made with a biopsy, new research shows recurrent cases are more accurately detected using PET imaging, or positron emission tomography. According to a team of radiologists and oncologists, 20-30 percent of the lesions that they detected through pet were missed by other techniques. PET proved to be more accurate in detecting both local recurrence and the spread of the cancer to lymph nodes, bone, liver and abdomen.

What is a PET scan?

Science behind the news is funded by a generous grant from the NSF

Before the advent of advanced medical imaging technologies, the only way to see inside the human body was to cut it open in surgery. Now PET scans, MRI's, X-rays and other imaging technologies help doctors see from the inside out.

A typical PET scanner is a large machine with a hole in the middle, shaped like a giant doughnut. It contains many rings of camera detectors. Once a patient has been injected with a radioactive substance, he or she lies on a sliding metal slab, which moves into the hole to begin the scanning process. The emitted radiation is detected by the cameras and that data is transmitted to a computer. The computer uses complicated mathematical formulas to arrange the data into a map of that region of the body, arranged according to different colors of degrees of brightness. For instance, more of the radioactive substance will accumulate in cancerous tissue than in normal tissue, so any cancerous areas will appear brighter on PET images. This is known as a "hot spot": cancerous tissue burns energy at a faster rate than normal tissue, a clear indication of malignancy.

PET is used to produce images of blood flowing through the body from the heart to detect heart disease. It can show how glucose (a primary energy source for the body) is broken down and used by the brain. PET scans of the brain are used to study patients with unexplained memory loss; they may have brain tumors or suffer from an undetected seizure disorder.

Positron Emission Tomography (PET) relies upon radioactive substances injected into the patient's body. A PET detects the gamma rays given off as radiation when atoms from the radioactive substance collide with atoms that make up body tissue. Then this data is used to compile an image of the area being scanned.


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Did you know?...

People with diabetes have abnormal blood sugar or blood insulin levels, which can cause a PET scan to give false results.

It takes 30 to 60 minutes for the injected radioactive substance to travel through your body and be absorbed by body tissue. After a PET scan, you should drink plenty of fluids to flush the radioactive substances from your body.

More information on this story

Martha J. Heil
mheil@aip.org
American Institute of Physics
Tel: 301-209-3088


© 2008 American Institute of Physics