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World's Smallest Microscope Focuses In On Cancer

Doctors Catch Cancer Sooner with World’s Smallest Microscope

August 1, 2011

Doctors are using the world’s smallest microscope to instantly detect cancerous or precancerous cells in the body. Instead of taking a biopsy and sending it for testing, doctors can simply guide the microscope into the patient’s esophageal tube and get images back in real time. The scope magnifies tissue up to a thousand times and is currently used to detect cancer in the gastrointestinal tract and lungs, but a study is underway to measure its effectiveness in urology as well.

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IMAGING THE DIGESTIVE SYSTEM: Colonoscopies are viewed as the "gold standard" for catching colorectal cancer before it has a chance to take root and spread. Gastroenterologists recommend that men and women over the age of 50, without a risk of colon cancer, get a colonoscopy every ten years, while those at high risk should receive them earlier and more frequently. During a colonoscopy, physicians visually examine the lining of the colon and rectum with an endoscope (small camera). The "scope" is passed through the rectum and into the colon to directly examine the lining of the lower digestive tract -- a full five feet of twists and turns. Upper endoscopies are used to examine the esophagus, stomach, and the upper part of the small intestine (the duodenum). The endoscope described in this story can also be used to examine other organs in the digestive tract, at a greater magnification than previously possible.

WHAT ARE LASERS: "Laser" stands for Light Amplification by Stimulated Emission of Radiation. The term describes any device that creates and amplifies a narrow, focused beam of light where the photons are all traveling in the same direction, rather than emitting light in all directions at once the way a flashlight or table lamp does. Laser light contains only one specific color, or wavelength. The type used in this segment, the confocal laser endomicroscope, produces blue light.

The Optical Society of America contributed to the information contained in the TV portion of this report.

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On The Web:

Miniature Microscope Can Improve Disease Detection, Diagnosis and Treatment

To Go Inside This Science: 

John Easton
(773) 795-5225
University of Chicago Medical Center
Medical Center Communications

The Optical Society of America
202-223-8130
info@osa.org


© 2011 American Institute of Physics