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Physics News Update
Number 477, March 31, 2000 by Phillip F. Schewe and Ben Stein

SIGNIFICANT BREAKTHROUGHS IN EARLY CANCER DETECTION, announced at last week's APS March Meeting in Minneapolis, apply physics techniques in new ways to detect disease. Employing light-scattering spectroscopy, in which one studies the colors deflected by an illuminated object, Michael Feld (617-253-7700, msfeld@mit.edu) and colleagues at MIT have developed a method for detecting the earliest signs of cancer in the epithelium, the layer of tissue lining the inner surfaces of the body such as the colon and bladder. An estimated 85 percent of all cancers begin in the epithelium, which often serves as the body's first line of defense against disease.

Usually, pathologists must biopsy epithelial tissue and rely on their experienced (but subjective) eyes to find signs of early cancer. Demonstrating a less invasive, more quantitative approach, the MIT researchers employ a narrow fiber-optic probe to shine white light onto epithelial tissue, and collect the light that the tissue deflects directly back to the probe. With this backscattered light, the MIT researchers could measure the index of refraction and spectral content in different regions of tissue.

This enabled them to map out areas (see Physics News Graphics) with such trouble signs as abnormal crowding of cells, enlargement of cell nuclei, and an increase in genetic material known as chromatin. Having successfully identified pre-cancerous colon and esophageal tissue in clinical tests, the researchers believe that their technique will reach the commercial market in the next few years.

Also at the meeting, Paul Gourley of Sandia (505-844-5806, plgourl@sandia.gov) presented a dime-sized "biocavity laser" that can detect cancer in the blood by examining only a few hundred cells--equal to about a billionth of a liter. (See http://www.sandia.gov/media/NewsRel/NR2000/candetec.htm)

THE BROADWAY INTERPRETATION OF QUANTUM MECHANICS "Copenhagen," a play by Michael Frayn about the 1941 encounter between Niels Bohr and Werner Heisenberg, was the subject of a daylong symposium this week at the City University of New York. Physicists, historians, and theater people involved with the production of the play (which opens soon on Broadway after a successful run in London) grappled with the central issue of why Heisenberg, at that time the chief scientist on the German atom-bomb project, should visit his old friend in occupied Copenhagen. Was he trying to learn about the Allies' atomic plans? Did he want to explore with Bohr the ethics of applying physics to the building of this most destructive of weapons? Should we view Heisenberg as a hero for purposely slowing or sabotaging the German bomb effort or an incompetent engineer who didn't know the difference between a reactor and a bomb?

The most poignant presentations at the symposium were made by Hans Bethe and John Wheeler, eminent physicists who themselves worked on the Allied bomb project and who knew Bohr and Heisenberg personally. Bethe declared that "Heisenberg had no interest in atomic bombs," citing as evidence the "Farmhall" tapes, the secretly recorded conversations of Heisenberg and the other German atomic scientists while in British custody after the war. News of the Hiroshima bomb was a great shock to the Germans who, while not very far along toward the development of a genuine atomic bomb, had felt they had gone further than the Allies.

Heisenberg's initial attempt to account for the Allied success in an impromptu tutorial for his colleagues seems to indicate that he was very far from understanding how a bomb would work. Wheeler spoke of several meetings with Heisenberg, including one at the University of Michigan in 1939 from which Heisenberg left early in order to return to Germany for military training. The reception of Heisenberg among physicists in the postwar years was often chilly, said Wheeler.

Not surprisingly, Heisenberg tried in later years to defend his honor, and on several occasions hazarded to explain the purpose of his 1941 visit. In one such explanation he maintained that he had come to Bohr to suggest that an atomic bomb would be too unmanageable to produce, that the German effort would not succeed, and that (by implication) the Allies should also give up the attempt. On this crucial point, historian Gerald Holton referred to a recently discovered letter written by Bohr to Heisenberg, but never posted. Holton has read the letter but it is otherwise sealed for another 12 years at the request of the Bohr estate. Without revealing the exact contents of the letter, Holton hinted that Bohr (in this unsent letter) took exception to what Heisenberg had been saying in public about their 1941 meeting.

Will there be any definitive judgment of Heisenberg? Probably not. The metaphorical thrust of Frayn's play is, of course, the extension of quantum uncertainty to the realm of human motivations, and in the course of the play, with its cyclic re-telling of the same event from differing perspectives, we are given to understand that Heisenberg himself was not sure of his own motivations in journeying to Copenhagen. http://inside.gc.cuny.edu/orup/copenhagen/)