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Physics News Update
Number 782, June 27, 2006 by Phil Schewe and Ben Stein

Making Radioactive Scorpion Venom Safe

At this week's meeting of the Health Physics Society in Providence, researchers will describe how they have helped establish the safety of a surprising new treatment for an aggressive, essentially incurable malignant cancer called high-grade brain glioma, diagnosed in more than 17,000 people in the U.S. every year.

The treatment is based on the discovery that the venom in the Israeli yellow scorpion (Leiurus quinquestriatus) contains a protein that binds selectively to the glioma cells. The procedure uses a compound called TM-601, a synthetic version of the venom protein attached to a radioactive substance called I-131 that kills the glioma cells. When injected into the bloodstream, the radioactive scorpion venom protein travels to the brain and attaches to the glioma cells, with the I-131 releasing radiation that kills the cells.

Describing the second sequence of phase II clinical trials involving human patients, health physicist Alan Jackson (AlanJ@rad.hfh.edu) of the Henry Ford Health System in Detroit will report that he and his colleagues recently established safe procedures for the therapy. Patients in the trial received a radioactive dose of 40 millicuries per week. This dose is not tremendously high compared to a thyroid cancer treatment, in which patients receive up to 200 millicuries of I-131 in a single treatment.

As Jackson determined, patients could safely return home several hours after the treatment, as their families would not be exposed to any more radiation than is typical with a thyroid cancer patient returning home after the procedure. And according to a separate group's study of the first sequence of phase II trials, patients receiving up to 40 millicuries of weekly dose did not show evidence of any adverse reactions attributable to the radiation. The phase II trial at Henry Ford involves 3 patients, with a total of 54 patients across the U.S. currently in investigational trials for the therapy.

Paper WAM-B.11 at the HPS 51st Annual Meeting, Wednesday, June 28, 2006
Study Demonstrates Safety of Promising Investigational Treatment for Deadly Brain Cancer (press release from TransMolecular, Inc.)

Warm Dense Gold

Physicists at Lawrence Livermore Laboratory in California have used intense light to convert a small solid gold target into a plasma of electrons and positive ions. In the instant before the sample flies apart the physicists are able to record some surprising results. The most important finding is that even at extreme conditions of high energy density (107 joules per kilogram), the gold metal still retains the band structure exhibited by all metals -- the allowed electron energies are not continuous but fall into certain allowed energy bands.

With light from a femtosecond laser falling on the sample, the Livermore scientists achieve the highest isochoric (meaning under conditions of constant density) energy density ever observed for a solid -- 107 joules per kilogram.

According to one of the researchers, Andrew Ng (ng16@llnl.gov), who is the scientific director of Livermore's Jupiter Laser Facility, expressing the energy density in terms of energy per unit mass, rather the customary energy per unit volume, gives a more direct sense of the excitation energy being invested in each atom or molecule. (Higher energy densities have been achieved by imploding a target with laser light or a nuclear explosion, but the new result is the highest for a sample at its original volume.)

Furthermore, this experiment achieves a record for heating rate -- exceeding 1017 degrees Fahrenheit per second -- for the electrons in the solid; the ions forming the lattice of the solid are heavier and warm up at a much slower rate.

This work can be considered as part of an emerging new subject, "warm dense matter," at the crossroads between condensed matter physics and plasma physics. This research area, related to another topic called high energy density physics, is also of interest to workers in disciplines such as high pressure science, planetary science, geophysics, and shock compression.

Ping et al., Physical Review Letters, 30 June 2006
Contact Andrew Ng, ng16@llnl.gov

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