Interview with Kevin Lesko, Senior Physicist at Lawrence Berkeley National Lab and former Spokesperson for LUX-ZEPLIN (LZ), an international collaboration searching for dark matter. Lesko explains why so many different kinds of physicists are involved in dark matter searches and how theorists have provided guidance for experimental and observational work to understand dark matter. He recounts his upbringing in northern California, the scientific influence of his parents and older siblings, and his decision to attend Stanford, where he worked on a tandem Van De Graaff in the nuclear physics lab. Lesko discusses his graduate work at the University of Washington, where he worked under the direction of Bob Vandenbosch on nuclear fission research, and he describes his postdoctoral appointment at Argonne, where he pursued experiments in nuclear fusion and neutrino physics. He explains his decision to join the staff at Berkeley Lab and how his interests centered increasingly on astrophysics with the Sudbury Neutrino Observatory. Lesko discusses his collaborations in Japan and KamLAND’s discovery of the absolute measurement of neutrino oscillations and the origins of the Homestake collaboration. He describes the transition of support for Homestake from the NSF to the DOE and he explains his entrée to the LUX collaboration and the reasons for the merger with ZEPLIN. Lesko explains how LZ needs to be ready to detect dark matter either as a singularity or is comprised of multiple components, and he considers what it might look like for dark matter to be detected. He recounts LZ’s success in ruling out dark matter candidates and he reflects on LBNL serving as a home base while his collaborative research has always been far-flung. At the end of the interview, Lesko considers what we have learned about the universe as a result of LZ, and why mystery and curiosity will continue to drive the field forward.