This is an interview with David Weitz, professor of physics and applied physics at Harvard. Weitz recounts his childhood in Ottowa, his decision to pursue an undergraduate education in Waterloo, and a formative summer experience at the Weizmann Institute which convinced him to become a scientist. He describes his graduate work at Harvard, where he worked in Mike Tinkham’s group and where he developed his thesis research on the Josephson effect. He discusses his postgraduate work at the laboratory at Exxon where he developed research on de Gennes soft matter physics. Weitz explains his decision to join the faculty at Penn at a time when the basic science culture at Exxon was coming to a close, and Harvard’s successful effort to recruit him shortly thereafter. He discusses his work as director of the Harvard Materials Research, Science and Engineering Center, how he became interested in biophysics and biomedical engineering and how he pursued entrepreneurial and culinary interests from a soft matter perspective. At the end of the interview, Weitz describes his current motivations in using soft matter physics to advance human health and improve fracking as a key part of the American energy system.