In this interview, David Zierler, Oral Historian for AIP, interviews Philip Anfinrud, Senior Biomedical Research Scientist, National Institute for Diabetes and Digestive and Kidney Diseases, at the National Institutes of Health. Anfinrud likens his work environment to the “Bell Labs of Biophysics” and he expresses his pride in working with colleagues conducting research at the cutting-edge of their respective fields. He recounts his upbringing in small town North Dakota and how he developed his early interests in atmospheric chemistry. Anfinrud describes the circumstances leading to his graduate work at Berkeley, and how he approached his interests in physics from a physical chemistry perspective. He describes his work with Walter Struve on energy transport and picosecond lasers, and he describes his postdoctoral research with Robin Hochstrasser at the University of Pennsylvania where he worked on infrared spectroscopy on the femtosecond time scale. Anfinrud discusses his first faculty appointment at Harvard, and he describes the process building a laser lab in partnership with Mitsubishi. Anfinrud explains his research on myoglobin and photolysis laser pulses, and he describes his first forays in X-ray radiation and crystallography. He describes his move to the NIH, where he created Laboratory of Ultrafast Biophysical Chemistry. Anfinrud explains the value of NMR spectroscopy to understand protein folding, and he describes how his interests are situated more in the realm of basic science and not clinically-oriented research. He discusses the value of scaling laws in physics as a means for understanding biochemical phenomena, and he describes the numerous ways that the NIH provides an ideal environment for research. At the end of the interview, Anfinrud provides an overview of his current research in time-resolved crystallography and single molecule behavior, and he describes the public health impact of his work on speech droplets as a means of transmitting the coronavirus.