In this interview, Lee Pondrom, Professor of Physics Emeritus at the University of Wisconsin, Madison, recounts his childhood in Dallas, San Antonio and Houston and describes his early interest in science. He explains his motivations to attend Southern Methodist University, where he pursued a degree in physics. Pondrom discusses his graduate work at the University of Chicago where the long-range influence of the Manhattan Project remained strong, even in the early and mid-1950s. He describes his summer research work at Los Alamos, and his thesis research on cyclotrons and pi mesons under the direction of Albert Crewe and Uli Kruse. Pondrom conveys the feeling of excitement at the discovery of parity violation while he was a graduate student, his postdoctoral work on the Nevis cyclotron while at Columbia, and he describes his Air Force service after he defended his dissertation. He describes the opportunities leading to his tenure at the University of Wisconsin and a research agenda that included long-term projects at the Chicago cyclotron, and at Fermilab and at Argonne. Pondrom discusses his contributions to CP violation, hyperon decay and how computers have been useful over the course of the career. He describes the origins of Fermilab and his experiences at Madison during the student unrest during the late 1960s, where bombers targeted science buildings. Pondrom discusses the significance of the E8 experiment as an extension of the Garwin-Lederman experiment and the origins of the Tevatron project. He explains the ups and downs of U.S. high energy physics during the SSC years and he surmises what would be known now in particle physics had the SSC been completed. At the end of the interview, Pondrom describes his extensive collaborations in Russia and his study of Soviet-era physics, including his work on Stalin’s nuclear diplomacy.