In this interview, John A. O'Keefe discusses his life and career. Topics discussed include: his family; Arthur Schlesinger; mathematics; cosmology; determinism; Catholicism; continental drift; Harvard University; Bart Bok; T. E. Sterne; astronomy; Cecilia Payne-Gaposchkin; Henry Norris Russell; composition of stars; Gerard Kuiper; Harlow Shapley; Grote Reber; radio astronomy; Yerkes Observatory; Fred Whipple; R Coronae Borealis variable stars; dark nebulae; Stan Ulam; John Oxley; University of Chicago; Otto Struve; McDonald Observatory; Ralph Williamson; S.