Mammography

In this interview, Peter McIntyre, Mitchell-Heep professor of experimental physics at Texas A&M University, and president of Accelerator Technology Corporation discusses his career and achievements as a professor. McIntyre recounts his childhood in Florida, and he explains his decision to pursue physics as an undergraduate at the University of Chicago and the influence of his longtime hero Enrico Fermi. He discusses his interests in experimental physics and he explains his decision to stay at Chicago for graduate school, where he worked with Val Teledgi, during a time he describes as the last days of bubble chamber physics. McIntyre conveys his intense opposition to the Vietnam War and the extreme lengths he took to avoid being drafted, and his dissertation work on the Ramsey resonance in zero field. He describes Telegdi’s encouragement for him to pursue postdoctoral research at CERN where he worked with Carlo Rubbia on the Intersecting Storage Rings project. He describes his time as an assistant professor at Harvard and his work at Fermilab, and the significance of his research which disproved Liouville’s theorem. McIntyre describes the series of events leading to his tenure at Texas A&M, and he explains how his hire fit into a larger plan to expand improve the physics program there. He discusses the completion of the Tevatron at Fermilab and the early hopes for the discovery of the mass scale of the Higgs boson, and he describes the origins of the SSC project in Texas and the mutually exclusive possibility that Congress would fund the International Space Station instead. McIntyre describes the key budgetary shortfalls that essentially doomed the SSC from the start, his efforts in Washington to keep the project viable, and the technical shortcomings stemming from miscommunication and stove-piping of expertise. He describes his involvement in the discovery of the top quark and the fundamental importance of the CDF, DZero, and ATLAS collaborations. McIntyre discusses his achievements as a teacher to undergraduates and a mentor to graduate students, and he assesses the current and future prospects for ongoing discovery in high energy physics. At the end of the interview, McIntyre describes his current wide-ranging research interests, including his efforts to improve the entire diagnostic infrastructure in screening and early detection of breast cancer.

Interview with Kyle Myers, Director of the Division of Imaging, Diagnostics, and Software Reliability in the FDA Center for Devices in Radiological Health. Myers recounts her childhood and the many moves her family made in support of her father's career in engineering management for General Electric, and she describes her father's formative influence and encouragement for her to pursue a career in science. She describes her college course work in physics at Occidental and Caltech, and she describes her decision to pursue a degree in optical sciences at the University of Arizona. She describes her work at the Jet Propulsion Lab and how this experience focused her interest on optics. Myers discusses working with her graduate advisor Harry Barrett on human perception and radiological imaging, and the importance of the research support she received from Kodak. She describes her postdoctoral work at Corning developing long-distance optical fibers, and she explains the circumstances leading to her career focus in medical imaging research at the FDA. Myers discusses the administrative evolution of the relevant offices and research centers at the FDA over the course of her career, and she discusses some of the major technological advances and her role in their development, including CT imaging, MRIs, and mammography screening. She describes some of the partnerships in the trade industry and across the federal interagency process that serve as important partners in her work, and she explains the adjudication process when a company is at odds with an FDA review of a given device. At the end of the interview Myers conveys her interest in the future prospects of digital pathology and the benefits it promises in disease detection and treatment.

Interview with Robert Jennings, retired since 2018 from the FDA’s Center for Devices and Radiological Health, where he was a research physicist. He recounts his childhood in Southern California and the formative influence of Sputnik on his physics education. Jennings discusses his undergraduate experience at Occidental and his master’s work at UCLA, and he describes his postgraduate work at the NASA Ames Research Center where he worked on optical detectors. He explains his decision to pursue a PhD at Dartmouth where he studied under John Merrill and worked on Tonks-Dattner resonances. Jennings describes the circumstances leading to his postdoctoral research in Brazil at the Institute of Atomic Energy, where he worked on medical radiation in the Division of Solid-State Physics. He discusses his subsequent research with John Cameron at the University of Wisconsin’s Medical Physics section to develop spectroscopy systems. Jennings explains that the expertise he developed in radiation and modeling in Wisconsin served as his entrée to the FDA ,which excited him as the place where the most impactful research was happening at the time. He surveys the major projects he was involved with over his career, including human visual signal detection, quality assessment of medical devices, improving mammography diagnostics, tomosynthesis, and CT scanners. At the end of the interview, Jennings surveys the fundamental developments that have advanced over the course of his forty-plus year career at FDA, his major contributions in tissue simulation science, and why he believes AI will become increasingly central to advances in medical imaging.