This is an interview with Edward Weiler, who served as chief scientist of the Hubble Space Telescope from 1979 to 1998, as NASA Associate Administrator for science activities from 1998 to 2004 and again from 2008 to 2011, and as director of the Goddard Space Flight Center from 2004 to 2008. The interview focuses primarily on his work relating to Hubble and the James Webb Space Telescope. Subjects addressed include his work developing international collaboration, and he explains the value of his strong working relationship with David Southwood of the European Space Agency. Weiler details his involvement with the correction of the spherical aberration afflicting Hubble’s primary mirror. He highlights NASA Administrator Dan Goldin’s role in establishing the scope of the Webb telescope, and he offers his views on the project’s troubles and the 2010 review chaired by John Casani that diagnosed sources of its cost growth and schedule slippage. Weiler also recounts his motivations for retiring from NASA in 2011, his activities since then, and he expresses his perspective on matters such as human space flight, lunar exploration, and the value of international partnerships in space science.