In this interview, Saul Perlmutter, Professor of Physics at UC Berkeley and Staff Scientist and senior faculty member at Lawrence Berkeley National Laboratory, discusses his life and career. Perlmutter shares that his research has not been slowed down by the pandemic by happy coincidence that he is currently focused on remote data analysis, and he recounts his childhood in Philadelphia where he was educated in Quaker schools. He discusses his early fascination with quantum mechanics and his decision to go to Harvard for his undergraduate education, where he cemented his interests in experimental physics. Perlmutter explains his decision to go to Berkeley for graduate school, where he worked in Buford Price’s group before Richard Muller became his graduate advisor. He discusses his early awareness of the cosmic microwave background and how he became involved with robotic searches for supernovae. Perlmutter describes the importance of NASA’s BITNET program as a way to connect observatory data worldwide to the computer systems at Berkeley, and he explains the intellectual and observational connections between the inflation, expansion, and acceleration of the universe. He discusses his postdoctoral research at Berkeley, and the circumstances leading to him becoming leader of the supernova group and how the DOE became more involved in astrophysics funding. Perlmutter explains the group’s focus on deceleration and he conveys the difficulties in scheduling telescope time to demonstrate spectroscopy proof of type Ia supernovae. He describes the origins of the SNAP satellite project, some of the early theoretical discussions on the nature of dark energy, and when, finally, his group secured long-term support from the Lab. Perlmutter narrates his first interactions with Brian Schmidt and Adam Riess and he describes the batch technique that could predict the discovery of supernovae, which vastly improved the efficiency of scheduling time on large telescopes. He explains the role of dark matter in speeding up the universe’s expansion, and he narrates the celebration with his team when he won the Nobel Prize and how he has chosen the use the political platform that comes with this recognition. Perlmutter discusses his interest in studying climate change, and at the end of the interview, he conveys his excitement about future observational discovery in astrophysics and cosmology.