Molecular biology

Interview with William Gelbart, Distinguished Professor of Chemistry and Biochemistry at UCLA. The interview begins with Gelbart discussing his research pertaining to COVID-19 and creating a vaccine. Gelbart then recounts his childhood in New York and describes growing up with a mathematician father. He takes us through his undergraduate years at Harvard where he majored in chemistry and physics. Gelbart speaks about his grad school experience at the University of Chicago and the trends in chemical physics at the time. He describes working under the mentorship of Stuart Rice, Karl Freed, and Joshua Jortner. Gelbart then details the factors that led him to a postdoctoral fellowship in Paris, followed by a postdoctoral position at UC Berkeley, at which time he transitioned into physical chemistry. Gelbart also discusses his subsequent move to UCLA and his collaborations with Avi Ben-Shaul. He explains his shift into biology and virus research, and his recent work on RNA gene expression and cancer vaccine research.

In this interview, David Zierler, Oral Historian for AIP, interviews Wayne Hendrickson, Violin Family Professor of Physiology and Cellular Biophysics at Columbia University. Hendrickson recounts his childhood on a dairy farm in Wisconsin and explains how this environment fostered his interest in the natural world. He describes his undergraduate experience at the University of Wisconsin at River Falls, and his formative work at Argonne Lab where he studied Caesium-137 levels in beagle dogs. Hendrickson describes his intent to focus on biophysics in graduate school and his decision to accept at offer at Johns Hopkins, where he became interested in protein crystallography and electron microscopy. He discusses his dissertation research under the direction of Warner Love and the importance of the research conducted at Woods Hole which influences his work on studying hemoglobin in lampreys. Hendrickson describes the importance of computational biology and the promises this offered protein crystallography, and he explains the influence of Linus Pauling in advancing the field. He explains why he stayed on at Hopkins after his defense because he felt there was more work for him to complete on the Patterson function. Hendrickson discusses his work at the Naval Research Laboratory on parvalbumin molecules and his developing interests in anomalous scattering techniques. He discusses how the field matured and had gained broader acceptance, and he surmises how these trends led to recruitment efforts that led to his tenure at Columbia in the 1980s. Hendrickson explains the labyrinthine nature of his many appointments and affiliations at Columbia, and the opportunities he has had to teach and to mentor graduate students within an environment that is primarily research-focused. He discusses the improvement of technology over the course of his time at Columbia, and he discusses his work on beamlines at Howard Hughes and Brookhaven. Hendrickson describes his work as scientific director of the New York Structural Biology Center, and he explains how his research has moved closer toward clinical motivations in recent years. At the end of the interview, Hendrickson reflects on his long career in biophysics, and he draws on the story of HIV infectivity as an example of how the field can progress from a place of really not understanding basic biological problems, to developing effective therapies.

In this interview, David Zierler, Oral Historian for AIP, interviews Philip Anfinrud, Senior Biomedical Research Scientist, National Institute for Diabetes and Digestive and Kidney Diseases, at the National Institutes of Health. Anfinrud likens his work environment to the “Bell Labs of Biophysics” and he expresses his pride in working with colleagues conducting research at the cutting-edge of their respective fields. He recounts his upbringing in small town North Dakota and how he developed his early interests in atmospheric chemistry. Anfinrud describes the circumstances leading to his graduate work at Berkeley, and how he approached his interests in physics from a physical chemistry perspective. He describes his work with Walter Struve on energy transport and picosecond lasers, and he describes his postdoctoral research with Robin Hochstrasser at the University of Pennsylvania where he worked on infrared spectroscopy on the femtosecond time scale. Anfinrud discusses his first faculty appointment at Harvard, and he describes the process building a laser lab in partnership with Mitsubishi. Anfinrud explains his research on myoglobin and photolysis laser pulses, and he describes his first forays in X-ray radiation and crystallography. He describes his move to the NIH, where he created Laboratory of Ultrafast Biophysical Chemistry. Anfinrud explains the value of NMR spectroscopy to understand protein folding, and he describes how his interests are situated more in the realm of basic science and not clinically-oriented research. He discusses the value of scaling laws in physics as a means for understanding biochemical phenomena, and he describes the numerous ways that the NIH provides an ideal environment for research. At the end of the interview, Anfinrud provides an overview of his current research in time-resolved crystallography and single molecule behavior, and he describes the public health impact of his work on speech droplets as a means of transmitting the coronavirus.

In this interview, David Zierler, Oral Historian for AIP, interviews Josef Eisinger, professor emeritus at the Mount Sinai School of Medicine. Eisinger recounts his childhood in Vienna and his experiences in England as a refugee from the Nazis during World War II. He talks about his transfer to Canada as an “enemy alien,” his experience transitioning to civilian life, and his matriculation at the University of Toronto, where he completed his undergraduate and Masters work in physics before transferring to MIT for his Ph.D. Eisinger discusses his work with Jerrold Zacharias and Viki Weisskopf. Eisinger discusses his tenure at Bell Labs, where he pursued a variety of interests in spectroscopy and electron-nuclear double resonance. He explains his developing interest in molecular biology and the Guggenheim Fellowships that allowed him to advance in this new field. He discusses his work on lead poisoning and his transition to Mount Sinai. Toward the end of the interview, Eisinger discusses his involvement with translating the letters of Brahms.