Interview with William Gelbart, Distinguished Professor of Chemistry and Biochemistry at UCLA. The interview begins with Gelbart discussing his research pertaining to COVID-19 and creating a vaccine. Gelbart then recounts his childhood in New York and describes growing up with a mathematician father. He takes us through his undergraduate years at Harvard where he majored in chemistry and physics. Gelbart speaks about his grad school experience at the University of Chicago and the trends in chemical physics at the time. He describes working under the mentorship of Stuart Rice, Karl Freed, and Joshua Jortner. Gelbart then details the factors that led him to a postdoctoral fellowship in Paris, followed by a postdoctoral position at UC Berkeley, at which time he transitioned into physical chemistry. Gelbart also discusses his subsequent move to UCLA and his collaborations with Avi Ben-Shaul. He explains his shift into biology and virus research, and his recent work on RNA gene expression and cancer vaccine research.