Dr. Han Wen runs the Imaging Physics Laboratory at the National Institute of Health. In this interview, Wen discusses his childhood in Beijing and the circumstances that led to his decision to pursue graduate studies in statistical quantum mechanics at the University of Maryland and its joint biophysics program that the Department of Physics ran with the NIH. Wen describes his early interest in MRI first as a graduate student at the NIH and then as a full time physicist. Wen provides an overview of his contribution to improvements in MRI technology and explains how the spirit of interdisciplinary collaboration at the NIH has enhanced his research. Wen explains his current work on x-ray CT imaging, which he hopes will improve in the future to the point when radiation exposure is minimized and the imaging quality becomes so good that many biopsies will no longer be necessary.