Interview with Rainer Weiss, professor emeritus of physics at MIT. Weiss recounts his family history in pre-war Europe and the circumstances of his parents' marriage. He describes his childhood in New York City, and he explains his interests in experimenting and tinkering from an early age. Weiss explains the circumstances leading to his undergraduate study at MIT and his original plan to study electrical engineering before focusing on physics. He recounts his long and deep relationship with Jerrold Zacharias, who singularly championed Weiss's interests over the years. He discusses his graduate work on the hyperfine structure of hydrogen fluoride. Weiss describes his formative work with Bob Dicke at Princeton, and he explains how technological advances was beginning to offer new advances in general relativity. He explains how Dicke's influence served as an intellectual underpinning for the creation and success of LIGO. Weiss emphasizes the importance of Richard Isaacson as one of the founding heroes of LIGO, and he describes the fundamental importance of joining his research institutionally with Caltech. He describes his early research with John Mather, and the numerous administrative challenges in working with the NSF throughout the LIGO endeavor. Weiss describes the geographical decisions that went into building LIGO, the various episodes when LIGO's ongoing viability was in doubt, and how both Barry Barish and Kip Thorne contributed to ensuring its success. At the end of the interview, Weiss describes some of the sensitivities regarding who has been recognized in LIGO and who has not, in light of all the attention conferred by the Nobel prize, and he reflects on how LIGO will continue to push discoveries forward on the nature and origins of the universe.