In this interview, David Zierler, Oral Historian for AIP, interviews Persis Drell, James and Anna Marie Spilker Professor in the School of Engineering, Provost of Stanford, and former Director of SLAC. Drell recounts her childhood as the daughter of the eminent physicist Sid Drell and what it was like to grow up in this milieu, and she emphasizes her lack of interest in physics as a child. She explains her decision to attend Wellesley for her undergraduate education, and she describes the benefits she felt she gained in attending a woman's college where Professor Phyllis Fleming turned her on to physics. Drell discusses her graduate work at Berkeley, where her key mentors were Gene Commins, Dave Jackson, and George Trilling and where she developed her thesis research on systematic errors that could cause false asymmetries. She describes her postgraduate work at Lawrence Berkeley National Laboratory where she switched to high-energy experimental physics and began her work at SLAC. Drell describes the changing culture at SLAC in the 1980s and 1990s, and the structural changes that compelled the Lab to branch out to new scientific pursuits. She discusses her decision to join the faculty at Cornell where she focused on data analysis for the CLEO particle detector and Cornell Electron-positron Storage Ring (CESR) projects, and conveys the supportive culture of Cornell. Drell describes the circumstances that compelled her to return to SLAC as director of research. She discusses the increasing importance of astrophysics and the B factory to SLAC's research agenda and the strategic challenges facing the Gamma-ray Space Telescope project. Drell explains the considerations leading to her being named lab director and some of the structural challenges in managing the relationship between SLAC and the Department of Energy (DOE). She describes the technical triumph of the Linac Coherent Light Source (LCLS) and the opportunities for better integration of SLAC with Stanford proper during her tenure, and she explains her decision to become dean of engineering at Stanford and then provost. Drell describes her most important responsibilities as provost, and at the end of the interview, she reviews some of the fundamental challenges that Stanford is facing as a result of the Covid-19 pandemic, and explains why, despite these challenges, students should feel optimistic about the future.