Interview with Henry Tye, professor emeritus of physics at Cornell, and subsequently professor emeritus of physics at Hong Kong University of Science and Technology (HKUST), and currently, Researcher at the Jockey Club Institute for Advanced Study at HKUST. Tye provides a brief history of HKUST, and he offers his views on China’s long-term goals in high energy physics. He recounts his childhood in Hong Kong where his family fled from mainland China during the Communist revolution, and he explains the opportunities that led to his undergraduate admission to Caltech. Tye describes how discussions of the Vietnam War permeated his college experience, and he describes the influence of Gerry Neugebauer on his interest in physics but that cosmology was far from his considerations at that point. He discusses his decision to study at MIT, where Francis Low became his advisor, and how he worked closely with Gabriele Veneziano on the relationship between the Thirring model and bosonic string theory. Tye explains the excitement surrounding the “November Revolution” which was unfolding just as he arrived at the SLAC Theory Group in 1974. He describes the origins of his interests in cosmology, and the source of his collaboration with Alan Guth during his postdoctoral work at Cornell, where he pursued matter-antimatter asymmetry. Tye explains how this collaboration ultimately created the field of inflation and why this addresses fundamental cosmological problems associated with flatness and the horizon. He explains how and why the original theory of inflation was revised by Andrei Linde and Paul Steinhardt, among others, and why he developed a subsequent interest in cosmic superstrings and branes which he recognized would give a perfect model for inflation. Tye describes why he is optimistic that technological advances will make cosmic superstrings a testable proposition, and that collaborations including the Sloan Digital Sky Survey and LIGO/Virgo are positive steps in that direction. He bemoans the dearth of string theorists focused on phenomenological work and why he thinks string theory will solve the quantum gravity problem. Tye describes his decision to join the Cornell faculty, why his notions of a “string landscape” suggest philosophical implications, why the cosmic landscape is central for understanding the wavefunction of the universe, and why both the universe and all multiverses can begin from truly nothing. At the end of the interview, Tye discusses his recent interests on the cosmological constant problem, the KLT relation, and the observations and experiments that are most likely to push cosmology into new and exciting areas of discovery.