In this interview Harold Agnew discusses topics such as: his time at the University of Chicago and Enrico Fermi; Columbia University; John Manley; George Weil; Los Alamos during World War II; Seth Neddermeyer; J. Robert Oppenheimer; George Kistiakowsky; Luis Alvarez; Bill Penny; National Science Foundation scholarship; nuclear physics; Laura Fermi; Richard Garwin; Don Hornig; General Atomics; Freddie de Hoffmann; Ed Creutz.