Edward “Rocky” Kolb is the Director of the Kavli Institute for Cosmological Physics at the University of Chicago and the Arthur Holly Compton Distinguished Service Professor of Astronomy at the University of Chicago. In this interview, Kolb explains how he acquired his nickname and he recounts his upbringing in New Orleans and his habit of spending time in the local library, where he developed his interest in science. He describes the financial constraints that compelled him to attend the University of New Orleans for college, and he characterizes his education there as broad but not deep, which caused him to consider a wide range of specialties for his graduate research at the University of Texas. Kolb describes working with his graduate advisor Duane Dicus in applying particle physics to cosmological questions, and he summarizes his dissertation research on the effects of axions in stars. He discusses his postdoctoral research with Willy Fowler at Caltech, and he emphasizes the influence of Allan Sandage on his decision to focus on cosmology. Kolb describes his second postdoctoral fellowship at Los Alamos where he joined the burgeoning astrophysics group in the Theoretical Division to work on Big Bang nucleosynthesis. He explains his decision to join the astrophysics group at Fermilab, where he collaborated closely with Michael Turner and benefited from the support of Leon Lederman. He describes his developing interest in supersymmetry and neutrino oscillations, he describes the impact of Alan Guth’s lectures on inflation, and he explains his increasing involvement with the astronomy and astrophysics department at the University of Chicago culminating with an offer for him to become chair of the department. He describes his objectives and achievements in that position, he explains how he maintained research interest in creating particles from the vacuum, and he describes how this research could be of value in the ongoing quest to understand dark matter. At the end of the interview, Kolb reflects on the different approaches that religion and science take to understanding reality, and he explains why he is most optimistic that understanding dark matter is the most likely major future breakthrough in his field.