Interview with Edward Witten, Charles Simonyi Professor in the School of Natural Sciences at the Institute for Advanced Study. Witten discusses his current interests in quantum information theory in gravity, and he recounts his childhood in Baltimore and the influence of his father Louis Witten, who is a physicist. He describes his undergraduate education at Brandeis, where he majored in history, a brief stint working for the McGovern campaign, and a false start in graduate school to study economics before landing at Princeton to study first applied mathematics and then theoretical particle physics with David Gross. He describes the significance of deep inelastic scattering in the emergence of QCD and his earliest exposure to the ideas that would develop into string theory. Witten describes his postdoctoral appointment at Harvard to work with Steve Weinberg, Sidney Coleman, Shelly Glashow, and Howard Georgi. He discusses t’ Hooft’s success at solving the U(1) problem and his early work in supersymmetry by the time he joined the faculty at Princeton. Witten narrates the string revolution of 1984 and the early optimism that string theory would be able to describe the real world. He describes his involvement in topological quantum field theories and he explains his decision to move to the Institute from Princeton. Witten discusses his work with Nati Seiberg on N=2 super Yang Mills in four dimensions, the origins of M-theory in the 1994 string revolution, and the impact of Juan Maldacena’s work on AdS/CFT. He describes his collaboration with Seiberg on noncommutative geometry, his interest in the Langlands program, and the role of axions in string theory. Witten conveys the sense of optimism when the LHC turned on and the significance of Khovanov homology and Morse theory. He explains the need to revisit perturbative superstring theory and the possibility that the g-2 muon anomaly experiment at Fermilab will lead to new physics. At the end of the interview, Witten reflects on how little has been seen at the LHC after the Higgs discovery, and he expresses hope that string/M-theory and quantum gravity make meaningful contact during his lifetime.